Dr. Prasanna's laboratory is part of the Department of Biomedical Engineering, a joint department within the School of Medicine and School of Engineering. Overall research theme in Prasanna's laboratory is to understand the mechanisms of cardiovascular diseases and develop innovative new therapies using technologies in modern medicine and bioengineering. Dr. Krishnamurthy’s laboratory focuses on several broad research areas: I) to study the molecular mechanisms involved in the progression of cardiovascular diseases II) understand how diabetes influences cardiovascular pathophysiology III) develop novel therapeutic strategies- to enhance stem cell therapeutic benefits (involving adult cells and induced pluripotent stem cells) and to promote cardiac regeneration and repair. Our laboratory uses molecular biology and modern classical research tools along with relevant surgical mouse models of cardiac diseases including myocardial infarction (LAD ligation), ischemia reperfusion and hypertrophy (ANG-II and TAC induced). Long-term goal of these studies is to identify new targets that can aid in development of future drugs and new therapies for prevention and treatment of cardiovascular disease complications in diabetes.

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Lab News updates

John successfully completed his PhD proposal defense (congratulations!)
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John Henderson's abstract on miRNA/phagocytosis is accepted for Oral presentation at BMES 2018, Atlanta (Congratulations John!).
The preliminary work shows the role of miRNA in phagocytosis and its implication on disease. 
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Premkumar Govindappa's abstract on Nanovesicles/cardiac fibrosis is accepted for poster presentation at BMES 2018, Atlanta (Congratulations Prem!).
The preliminary work shows the role of exosomes in cellular interaction and its implication on fibrosis. 
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Darukesh receives two-year AHA Postdoctoral fellowship award
for his research proposal that will study role of Serine Threonine Kinases in endothelial progenitor cells (EPC) under diabetic conditions (work supported through AHA funds from Jul 2015-Jun 2017). 
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Manuscript accepted for publication in Scientific Reports (congratulations Sahana). 
The work demonstrates that miR-126 overexpression rescues diabetes-induced impairment in macrophage clearance of dead cardiomyocytes.  
Read article
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Manuscript accepted for publication in Biochem Biophys Res Commun. (Congratulations Prince!).
The work demonstrates that miR-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes. 
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HMRI President’s Award for Transformational Excellence-Peer Reviewed Publication (Congratulations to the team!). 
The award was given to the team for publication in J Am Coll Cardiol. (please see the title below). 
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Manuscript accepted for publication in J Am Coll Cardiol. (Congratulations Darukesh!). 
The manuscript is titled "Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377". 
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Dr. Krishnamurthy elected a "Fellow of American Heart Association (FAHA)"
This is a distinguished award conferred by the AHA to recognize scientists for excellence, innovative and sustained contributions in the areas of scholarship, education, and volunteer service and/or leadership within the AHA/ASA.
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Rajarajan receives two-year AHA Postdoctoral fellowship award
for his research proposal that will study macrophage cell-based therapy for cardiac regeneration and repair under diabetic conditions (work supported through AHA funds from Jul 2015-Jun 2017). 
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Prasanna receives AHA Grant-in-Aid award
This study will evaluate the effect of diabetes on EPC/human CD34 cell senescence and its implications on cardiovascular regeneration after injury (work supported through AHA funds from Jul 2015-Jun 2017). 
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Prince awarded AHA-BCVS New Investigator Travel Award 

He will present his research work on mRNA stability in cardiac fibrosis and dysfunction at AHA-BCVS symposium, New Orleans, USA. 
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Manuscript accepted for publication in Experimental Dermatology (Congratulations Rajarajan!). 
The work demonstrates that Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing. 
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Darukeshwara receives Best Poster Award 
for his work on miRNAs in human CD34 cell biology and function at George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Inaugural International Meeting, Houston Methodist Research Institute, TX. 
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Best Poster Award Finalist (Congrats Rajarajan!) 
Work presented at Gulf Coast Cluster (GCC) for Regenerative Medicine Symposium, Rice University, Houston, TX.