2013129105450.head shot s47Peter D. Burrows, PhD
My laboratory is interested in the development and function of B lymphocytes. Immunoglobulin gene rearrangements as well as a number of critical changes in gene expression take place as cells progress through this differentiation pathway. We have been using both cellular and molecular approaches to identify novel genes whose expression is developmentally regulated. Defects in the expression of such genes could lead to immunodeficiency, whereas inappropriate expression might predispose a cell to malignant transformation. One such gene that we identified is a novel Fc receptor-related gene, FCRLA, which is found in the endoplasmic reticulum of germinal center B lymphocytes. FCRLA is unique in its ability to associate with multiple immunoglobulin isotypes IgM, IgG and IgA.

Current areas of research include:

  • Function of a novel intracellular Fc Receptor-related protein in B cells
  • Function of the putatively B cell-specificmb-1gene in non-B cells

Our laboratories are located in Shelby Biomedical Research Building.

We are members of the Department of Microbiology at the University of Alabama at Birmingham