MG Group            
   The Goldberg Lab is an outstanding training environment for students, postdocs and other lab members to collectively achieve the overall research mission, which is to understand how genetic mutations cause inherited forms of Parkinson’s disease (PD). The long term goal is to gain sufficient understanding of PD pathogenic mechanisms to develop and test novel therapies that can prevent the loss of dopamine-producing neurons, which underlies the major clinical symptoms of PD. There are currently no therapies proven to slow down the progression of PD. We have made important progress towards this goal by analyzing cell and animal models of PD bearing genetic mutations causally linked to familial PD, including mutations in Parkin, DJ-1, PINK1, alpha-synuclein and LRRK2. Ongoing research projects funded by grants from the National Institutes of Health and the Michael J. Fox Foundation for Parkinson’s Research include developing methods to manipulate LRRK2 function, enhance mitochondrial autophagy and protect against oxidative stress in order to test neuroprotective strategies.