Active Research Support

R01CA183991  (PI: Nakano)                                                                                                                 02/15/2015 - 01/31/2020
NCI                                                                                                                                                     $306,984 (Direct Dollars)
Novel role of compensatory proliferation in human brain tumor
The goal is to determine whether inter-cellular signaling between therapy-induced dying tumor cells and surviving cells leads to creation of recurrent tumors with even more therapy resistant phenotype.
Role – Principal Investigator

R01CA201402 (PI: Cerione, Nakano)                                                                                                 12/04/2015 - 11/30/2020
NCI: Distribution from Cornell                                                                                                            $451,697 (Direct Dollars)
The roles of a unique GTP-binding protein/crosslinking enzyme in disease
The goal is to understand the biological roles of TGase-2 in disease, as well as identify novel therapeutic targets for EGFR/EGFRvIII-driven cancers such as GBM.
Role – Principal Investigator (Multi PI)

R01NS093843 (PI: Cheng)                                                                                                                  09/01/2015 - 05/31/2020
NINDS: Subaward from Northwestern                                                                                                $354,908 (Direct Dollars)
Glioblastoma Phenotype Modulation Through miRNA Control of Wnt Signaling
The goal is to understand how aberrant miR expression and Wnt signaling activity contribute to glioma malignancy.
Role – Subaward Principal Investigator

R25NS079188 (PI: Standaert)                                                                                                             07/01/2016-06/30/2022  
NINDS                                                                                                                                                 $44,269 (Direct Dollars)               

UAB Research and Education Program in Neuroscience
The goal is to support residents in neurology, neurosurgery, and neuropathology who are pursuing careers combining clinical practice and research, and foster their development as physician-scientists
Role – Associate Director

R01CA208851 (PI: Turkson)                                                                                                             03/01/2017 - 02/28/2022            
NCI: Subaward University of Hawaii Cancer Center                                                                         $610,274 (Direct Dollars)
STAT3, G6PD AND TRxR as Underlying Mechanisms for Antitumor Responses to Hirsutinolides           
The goal of this proposal is to facilitate the development of the hirsutinolides as potential therapeutics for breast cancer and GBM.   

Role – Subaward Principal Investigator                                

P30CA013148 (PI: Birrer)                                                                                                                  04/01/2016 – 03/31/2022
NCI                                                                                                                                                      $124,983 (Direct Dollars)
Comprehensive Cancer Center Core Support Grant - Neuro-Oncology Program
The mission of the NOP is to consistently translate contemporary research discoveries to safe and efficacious therapies for adult and pediatric patients with brain cancer.
Role –  Co-Leader

R01NS107071 (PI: Nakano)                                                                                                              05/01/2019 – 03/31/2024
NINDS                                                                                                                                                 $320,209 (Direct Dollars)
Radiation-Induced Crosstalk of Immune Glioma Stem Cells
The overall goal is to elucidate the mechanisms by which mesenchymal glioma stem cells acquire a therapy-resistant phenotype.
Role –  Principal Investigator

Completed Research Support (past 5 years)

R01NS083767 (PI: Nakano, Lee)                                                                                                       07/1/2013-06/30/2019         
NINDS                                                                                                                                                Complete  
Targeting MELK-mediated EZH2 signaling in glioma stem cells      
The goal of this project is to find a new paradigm for glioma stem cell (GSC) biology and a novel therapeutic approach to target key regulators of GSC.
Role – Contact PI

R01NS083629 (PI: Lathia)                                                                                                                  07/15/2013 – 06/30/2018          
NINDS: Subaward from Cleveland Clinic                                                                                          Complete   
Novel adhesion mechanisms in glioblastoma stem cells         
The goal of this project is to uncover the critical role of CSC interaction with the niche via JAM-A and evaluate potential therapies to GBM which disrupt niche related communication.
Role – Subaward PI

R01NS087913 (PI: Rich, Nakano)                                                                                                       04/15/2014 - 02/28/2019
NINDS: Distribution from Cleveland                                                                                                   Complete
Metabolism informs intertumoral & intratumoral heterogeneity
The goal of this project is to translate our findings to develop therapeutics targeting the dysregulated metabolic signaling in GBM.
Role – Principal Investigator (Multi PI)

Foundation Support (PI: Nakano)                                                                                                     03/01/2018-02/28/2019
Breast Cancer Research Foundation at Alabama                                                                                 Complete
Metastatic breast cancer to the brain and the role of ALDH1A3 in brain metastasis
Role – Principal Investigator

R21CA198648 (PI: Iyer)                                                                                                                     05/19/2016-04/30/2018
NCI: Subaward UT Austin                                                                                                                  Complete
Novel role of the Polycomb repressive complex PRC2/EZH2 in glioblastoma
The goal is to establish, characterize and use patient-derived glioma neurosphere cultures and their mouse xenograft brain tumors to investigate the physiological role of EZH2 association with short NRAs in glioma stem cells
Role – Subaward PI

R01NS083767 (PI: Nakano)                                                                                                               07/01/2013-06/30/2018
NINDS                                                                                                                                                 Complete
Targeting MELK-Mediated EZH2 Signaling in GLioma Stem Cells
Role – Principal Investigator

R01NS083629 (PI: Lathia)                                                                                                               07/15/2013-06/30/2018
NINDS                                                                                                                                                 Complete
Novel Adhesion Mechanisms in Glioblastoma Stem Cells
Role – Co-Investigator

N/A (PI: Nakano)                                                                                                                                03/01/2017-02/28/2018
Breast Cancer Research Foundation at Alabama                                                                                Complete
Targeting Metastasis-Initiating cells in Heterogeneous Circulating Breast Cancer Cells
Role – Principal Investigator                                                                                                 

P01CA163205 (PI: Nakano)                                                                                                               02/07/2013-01/31/2018
NCI                                                                                                                                                      Complete
Malignant Gliomas Biorepository Core
Role – Principal Investigator  

R21CA192042 (PI: Verbridge)                                                                                                           02/15/2015-01/31/2017
NCI                                                                                                                                                      Complete
Targeted Electric Field Therapy for Malignant Infiltrative Glioma
Role – Co-Investigator

R21CA175875 (PI: Nakano)                                                                                                              01/01/2014-12/31/2016
NCI                                                                                                                                                      Complete
Determination of Musashi/CD44V6 Signaling in Mesenchymal Glioma
Role – Principal Investigator