Grant Support

Ongoing Research Support

Alabama Enrichment Fund                                                  Chen (PI)                                                  10/1/15-9/30/25
Signaling Pathways in Endocrine Malignancies                                
This $2 million grant focuses investigating signaling pathways which regulate the proliferating of endocrine cancers and on developing novel strategies to translate laboratory findings to the clinics.

NIH/NCI KO8 CA234209                                                    Rose (PI)                                                   7/1/19-6/30/24
Targeted Treatment of Metastatic Gastroenteropancreatic Neuroendocrine Tumors

NIH/NIDDK T35 DK116670-01                                           Chen/Locke (PI)                                        4/1/19-3/31/24
Short-Term Research Experiences Advancing Medical Students
The goal of this grant is to train medical students in translational and health services research.

NIH/NCI RO1CA228399                                                    Olson (PI)                                                  12/1/18-11/30/23
Parathyroid Tumor Clonal Status as a Biomarker in Primary Hyperparathyroidism
This sub-contract from the University of Maryland is to study clonality in patients with hyperparathyroidism. Dr Chen serves as the UAB PI under subcontract.

NIH/NCI T32 CA220102                                                    Kennedy (PI)                                             7/1/18-6/30/23
Surgical Oncology Research Training Program
The goal of this grant is to train surgeons in cancer research and investigation. Dr. Chen serves as Associate Program Director.

Novo Nordisk                                                                     Chen (PI)                                                  11/1/18-10/31/22
Medullary Thyroid Carcinoma Surveillance Study
This proposal is a national effort to understand the incidence and etiology of medullary thyroid cancer.

NIH/GM KO8 GM101361                                                   King (PI)                                                    8/1/14-7/31/19
The Role of Notch2 and Notch3 in Cutaneous Wound Healing
This proposal studies the role of notch signaling in wound healing. Dr. Chen serves as mentor for this project.

Howard Hughes Medical Institute                                      Carmona Matos (PI)                                  8/31/18-8/30/19
Antibody-drug conjugate (ADC) for medullary thyroid cancer (MTC) targeted therapy.
This proposal studies somatostatin receptor 2 (SSTR2) immunotherapy for MTC. Dr Chen and Dr Jaskula-Sztul serve as mentors on this project. 

ACS-IRG Junior Faculty Development Grant                    Jaskula-Sztul (PI)                                      3/1/19-2/28/20
Pharmacological overexpression of somatostatin receptor type 2 (SSTR2) in pulmonary neuroendocrine tumors for improved [68Ga]DOTATATE imaging and treatment.
This proposal studies the overexpression of SSTR2 by HDAC inhibitors for improved imaging with [68Ga]DOTATATE and potential treatment with [177Lu]DOTATATE in pulmonary neuroendocrine tumors.

NANETS Basic/Translational Science Investigator           Jaskula-Sztul (PI)                                    9/1/18-8/31/20
Novel antibody-drug conjugate (ADC) for pancreatic neuroendocrine tumor (PanNET) targeted therapy.
This proposal explores drug delivery to PanNET via an anti-somatostatin receptor 2 (SSTR2) monoclonal antibody linked to natural compounds tested in patient derived samples.

UAB Radiology/CCTS Pilot Research Initiative                 Jaskula-Sztul (PI)                                  10/31/18-10/31/19
Imaging of alterations in SSTR2 expression with HDAC inhibitors treatment for neuroendocrine tumors.
The goal of this proposal is to increase SSTR2 density with HDAC inhibitors in human NET xenografts for improved detection.

Completed Research Support

American Cancer Society MEN2 RSG                              Chen (PI)                                               7/1/13-6/30/18
Notch signaling in Medullary Thyroid Cancer
This project focuses on translating Notch signaling in medullary thyroid cancer.

UAB CCC Faculty Development Grant                             Jaskula-Sztul (PI)                                   8/1/17-7/30/18
Somatostatin receptor 2 (SSTR2) antibody-drug conjugate for pancreatic neuroendocrine tumor (PanNET) therapy.
This proposal explores drug delivery to PanNET via an anti-somatostatin receptor 2 (SSTR2) monoclonal antibody linked to natural compounds.

UAB CCTS Multidisciplinary Pilot Grant                            Jaskula-Sztul (PI)                                   5/1/17-4/30/18
Synaptic vesicle 2 receptors as a novel targets for neuroendocrine cancer therapy.
This proposal explores drug delivery to neuroendocrine tumors via synaptic vesicle 2 receptor therapy.

UAB Bioengineering Surgery Collaborative Pilot Grant    Jaskula-Sztul (PI)                                   4/1/17-3/31/18
SSTR3 and GIPR Antibody-Drug Conjugates for Pancreatic Neuroendocrine Tumor Therapy.
This proposal explores drug delivery to PanNET via an anti-somatostatin receptor 3 (SSTR2) and GIPR antibody drug conjugate.

UAB Bioengineering Surgery Collaborative Pilot Grant    Jaskula-Sztul (PI)                                   4/1/17-3/31/18
Development of an engineered medullary thyroid cancer (MTC) surrogate system as a preclinical model for personalized drug screening.
This proposal explored the use of a novel bioreactor system to grow MTC tissues and treat these tissues with therapeutic compounds to identify effective therapies.

UAB CCC New Faculty Award in Cancer Research         Jaskula-Sztul (PI)                                    8/1/16-7/31/17
Tumor-Targeting Nanotheranostic Micelles for Neuroendocrine Cancer Therapy. 
This project looked at the use of micelles to deliver drugs to neuroendocrine tumors.

Caring for Carcinoid Foundation-AACR               Chen (PI)  Jaskula-Sztul (Co-PI)                          7/1/14-6/30/17
Multifunctional Nanomedicine for Targeted Carcinoid Cancer Therapy
This project seeks to develop nanoparticles for carcinoid tumors.

American Cancer Society                                     Chen (PI)                                                             1/1/11-4/30/17
MEN2 Thyroid Cancer Professorship
This professor is to lead a consortium of medullary thyroid cancer investigators.

A.W. Memorial Fund NE Carcinoma                    Chen (PI)  Jaskula-Sztul (Co-PI)                          7/1/15-6/30/17                            
A Pilot Study on Targeted Delivery of Thailandepsin-A, a New Type of Natural Small Molecule Class I HDAC Inhibitor to Neuroendocrine Cancers using Unimolecular Micelles

NIH/GM R01 GM104192-01                                 Bugni (PI)  Chen (Collaborator)                           5/1/13-6/30/17           
Omics approaches for natural products discovery
NIH/NCI RO1 CA121115                                      Chen (PI)                                                              5/1/09-4/30/15            
GSK3-beta Signaling in Medullary Thyroid Cancer

NIH/NCI RO1 CA109053                                     Chen (PI)                                                              8/1/06-7/31/12            
Regulating Neuroendocrine Phenotype in Cancer

NIH/NCI T32 CA090217-11                                 Chen (PI)                                                              7/1/11-2/29/16     
Surgical Oncology Research Training Program

NIH/NIDDK T35 DK062709-06                           Chen (PI)                                                              4/1/11-9/30/15     
Surgery Summer Research Experience for Medical Students

NIH/NCI RO1 CA121115-02S1                          Chen (PI)                                                              5/18/10-2/1/13     
Minority Supplement for Yvette Carter

Doris Duke Charitable Foundation                     Chen (PI)                                                              1/1/12-9/30/15     
Surgery Clinical Research Experiences for High School Students
NIH/GM R13 GM09523                                      Chen (PI)                                                              10/1/11-9/30/14     
AAS Courses to Increase Women and Minorities in Academic Surgery 

Doctors Cancer Foundation                                Chen (PI)                                                              7/1/07-6/30/12    
The Role of GSK3B in Carcinoid Cancers 

L.C.A Faculty Research Fellowship (ACS)        Chen (PI)                                                                7/1/11-6/30/12 
Cutaneous Wound Healing with Notch Signaling 

UWCCC/Wisconsin Discovery Institute                Chen (Co-PI)                                                       7/1/12-6/30/15     
Co-delivery of siRNA and Anticancer Drug using Multifunctional Au NR-based Nanocarriers for Targeted Neuroendocrine Cancer Therapy

University of Wisconsin-Madison/Milwaukee       Chen (Co-PI)                                                        8/1/12-7/30/14    
Novel Nanomedicines for Targeted Neuroendocrine Cancer Therapy

Novartis                                                               Chen (Co-PI)                                                        4/20/09-4/1/14    
A Phase II Clinical Trial of LBH589 for Thyroid Cancer

American College of Surgeons                           Burke (PI) Chen (Mentor)                                    7/1/11-6/30/13
Targeting Notch in Medullary Thyroid Cancer

American Association of Plastic Surgeons         King (PI) Chen (Mentor)                                      7/1/11-6/30/13
The Use of Notch Mediating Compounds to Improve Cutaneous Wound Healing 

Novartis                                                               Chen (Co-PI)                                                       5/1/09-5/1/12    
A Phase II Clinical Trial of LBH589 for Gastrointestinal Neuroendocrine Cancers

NIH/NCI 8515                                                      Le Conte (PI) Chen (Co-PI)                                4/20/09-5/1/12  
A Phase 1 Study of RO4929097 (NSC749225) in Combination with Capecitabine in Refractory Solid Tumors

L.C.A Faculty Research Fellowship (ACS)        Chen (PI)                                                             7/1/11-6/30/12 
Cutaneous Wound Healing with Notch Signaling 

NANeTS                                                            Mazeh (PI) Chen (Mentor)                                   7/1/11-6/30/12
Notch 2 and 3 in Neuroendocrine Cancers 

Howard Hughes Medical Institute                      Somnay (PI) Chen (Mentor)                                7/1/11-6/30/12
Signaling in Carcinoid Cancers  

University of Wisconsin SMPH                           Chen (PI)                                                             2/1/10-1/31/11
The Role of Notch1 Signaling in Wound Healing

American College of Surgeons                           Zarebczan (PI) Chen (Mentor)                            7/1/09-06/30/11
Novel Therapeutic Strategies for Neuroendocrine Cancers 

Carcinoid Cancer Foundation                             Chen (PI)                                                             9/1/06-8/31/10 
Modulating Raf-1 Signaling in Carcinoid Cancer 

ACS George Clowes Memorial Award                Chen (PI)                                                             7/1/04-6/30/10
Inhibition of Gastrointestinal Neuroendocrine Tumor Progression by Signal Transduction Pathways

NIH/NCI R21 CA117117                                      Chen (PI)                                                             6/15/07-5/31/10
Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors

Novartis                                                              Chen (PI)                                                              10/31/08-12/31/09
Combination Raf-1 activation and Octreotide in Neuroendocrine Cancer

Society of Surgical Oncology                            Chen (PI)                                                                6/1/07-6/30/09
Clinical Trial of GSK3B Inhibitors for Neuroendocrine Cancers

UW Comprehensive Cancer Center                  Chen (PI)                                                               7/1/07-6/30/09
The Role of GSK3B inhibition by Lithium as a Therapy for Patients with Advanced Medullary Thyroid Cancer

UW Comprehensive Cancer Center                   Holen (PI) Chen (Co-PI)                                        7/1/07-6/30/09
A Preliminary Clinical Trial of Valproic Acid for Patients with Metastatic GI Neuroendocrine Cancers 

Howard Hughes Medical Institute                      Cook (PI) Chen (Mentor)                                     8/1/08-8/31/09
HDAC inhibitors and Notch1 

American College of Surgeons                            Pitt (PI) Chen (Mentor)                                       7/1/07-6/30/09
Signaling Pathways in Gastrointestinal Neuroendocrine Tumors 

Association for Academic Surgery                      Pinchot (PI) Chen (Mentor)                                 7/1/07-6/30/09
The Role of GSK3B Pathway in Gastrointestinal Neuroendocrine Tumors

Association for Academic Surgery                      Greenblatt (PI) Chen (Mentor)                            7/1/05-6/30/09
Notch1 Signaling in Gastrointestinal Neuroendocrine Tumors 

Howard Hughes Medical Institute                        Adler (PI) Chen (Mentor)                                    7/1/07-6/30/08  
Dissecting the Mechanism of Notch1-mediated hormone Suppression in Gastrointestinal Neuroendocrine Cancer 

American Cancer Society RSG TBE-108768     Chen (PI)                                                               1/1/05-12/31/08
Endocrine Differentiation and the Role of Notch1  

Vilas Foundation                                                Chen (PI)                                                                7/1/06-6/30/08
Neuroendocrine Cancers: Signaling-based Therapies

NIH/NIDDK R21 DK066169                               Chen (PI)                                                               2/1/04-1/31/07 
Novel Signaling Targets in GI Neuroendocrine Tumors

NIH/NIDDK R21 DK064735-01                         Chen (PI)                                                               7/1/03-6/30/05 
Signaling Pathways in Medullary Thyroid Cancer 

Robert Draper Technology Innovation Fund      Kunnimalaiyaan (PI) Chen (Mentor)                 1/1/05-12/31/05
The Role of Lithium Chloride in Tumor Suppression 

NIH/NIDDK R21 DK063015-01                         Chen (PI)                                                               1/1/03-12/31/04 
Notch1 Signaling and Gastrointestinal Neuroendocrine Tumors 

American Surgical Association Foundation      Chen (PI)                                                              7/1/02-6/30/04 
Gastrointestinal Neuroendocrine Tumors: A Possible Therapeutic Role for the ras/raf-1 signal transduction pathway 

Robert Draper Technology Innovation Fund     Chen (PI)                                                             7/1/03-6/30/04 
A Novel Drug for Neuroendocrine Tumors 

University of Wisconsin                                     Kunnimalaiyaan (PI) Chen (Mentor)                 10/1/03-12/31/04
Construction of Inducible Notch1 and its Role in Medullary Thyroid Cancer 

Howard Hughes Medical Institute                      Van Gompel (PI) Chen (Mentor)                         7/1/03-6/30/04
The Role of Human Achaete-scute Homolog-1

University of Wisconsin Graduate School           Chen (PI)                                                          7/1/03-6/30/04
Notch1 Signaling in Gastrointestinal Tumors

Howard Hughes Medical Institute                         Chen (PI)                                                          7/1/01-6/30/03
A novel therapy for neuroendocrine tumors 

American Medical Association                               Musunuru (PI) Chen (Mentor)                          9/1/02-5/31/03 
Carcinoid Heart Disease 

University of Wisconsin Medical School                   Chen (PI)                                                       10/1/01-9/30/02
The role of insulin-like growth factor-I in GI carcinoid tumors 

Society of Surgical Oncology                                 Chen (PI)                                                         1/1/01-12/31/01
The role of the ras/raf-1 signal transduction pathway in neuroendocrine tumor progression and metastases 

American Cancer Society IRG-58-011-44-04         Chen (PI)                                                       11/1/00-10/31/01 
Raf-1 signaling in neuroendocrine tumors

NIH/NCI NRSA-CA67481                                        Chen (PI)                                                         4/1/95-6/30/97
The transcriptional regulation of human achaete-scute homolog-1 

Howard Hughes Medical Institute                            Chen (PI)                                                          9/1/90-8/31/91
HIV-1 regulatory proteins