Research

Current Research

Glycosylation of the GluR2 AMPA receptor subunit in frontal cortex in schizophrenia

Abnormal subcellular localization of EAAT isoforms in schizophrenia

Expression profiles of  TARP proteins in subcellular fractions from postmortem human brain in schizophrenia

N-glycosylation of GABA receptor subunits

Molecular pathways underlying schizophrenia

Palmitoylation in Schizophrenia

Using LCM-qPCR to Study Cell Specific Patterns of Gene Expression in Schizophrenia


Past Research

Fractionation of subcellular structures from postmortem brain tissue.

Cortical expression of PSD proteins in schizophrenia, major depression, and bipolar disorder.

Striatal expression of transcripts for NMDA associated PSD proteins in schizophrenia, major depression and bipolar disorder

Cortical expression of NMDA receptor subunits and PSD proteins in schizophrenia

Analysis of the interaction between metabotrophic and ionotrophic glutamate receptors in schizophrenia

Analysis of NMDA related trafficking molecules in schizophrenia

NMDA receptor subunit and PSD protein mRNA expression in hippocampus of human postmortem brain samples.

Thalamic expression of NMDAR subunits and associated PSD protein transcripts following exposure to antipsychotic drugs.

Characterization of excitatory amino acid transporter interacting proteins in the cortex in schizophrenia.

Excitatory amino acid transporter (EAAT) expression in the prefrontal cortex and thalamus in schizophrenia.

Expression of vesicular glutamate transporters (vGLUTs) in the medial temporal lobe in severe psychiatric illness.

Modulation of excitatory amino acid transporter (EAAT) expression with Sindbis virus vectors in rodent brain slices.

Expression of glutamate transporter – associated protein transcripts in thalamic nuclei from postmortem human brain samples.

Studies of Dopamine Receptor Transcript Abnormalities in the Cortex and Striatum in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.