Tree Shrew Myopia
Translating experimental observations into multi-scale computational models to investigate scleral remodeling in myopia.
Simulating Keratoconus
Computational remodeling simulation provides new insight into keratoconus progression.
Fluorescence Microscopy
Advancements in fluorescence microscopy provide new possibilities to quantify collagen remodeling in living tissues.
Organ Culture
Collagen remodeling takes time. Our new portable organ culture system allows us to investigate scleral remodeling in situ.

Welcome to the GRYTZ lab

Our eyes are composed of living tissues, which are constantly remodeling in response to mechanical, chemical, and visual stimuli. In particular, the loadbearing collagenous structures of the eye can undergo substantial growth and remodeling during physiological and pathophysiological conditions. Our research is driven by the desire to elucidate the biomechanical mechanisms that underlie growth and remodeling in ocular conditions and diseases such as myopia, glaucoma, and keratoconus. Ongoing projects include the investigation of visually guided mechanisms controlling the axial length of the eye through scleral remodeling; the intraocular pressure-driven remodeling of the optic nerve head in glaucoma; and loss and weakening of stromal collagen in keratoconus. The laboratory’s goal is to develop experimental and computational methods to quantify and simulate growth and remodeling of the eye that support the development of new diagnostics and patient-specific therapeutics in ocular diseases and conditions.

Our laboratory is part of the Ocular Biomechanics and Biotransport Program at UAB, where we share a common goal to use the principles of engineering to understand the mechanisms underlying ocular diseases.