The Roberson Lab


Medical-Research

Our mission is to understand the neurobiology of Alzheimer's disease
and frontotemporal dementia and to develop new treatments for these conditions.



Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the leading causes of dementia. Neither has highly effective treatments available. The microtubule-associated protein tau is a major focus in the Roberson lab, as it plays important roles in both diseases. We also study progranulin, a common genetic cause of FTD. We are particularly interested in the how these molecules affect vulnerable brain networks the default mode network in AD and the salience network in FTD to cause neuronal dysfunction. We use mouse models and other approaches to address these questions.